On the 75th anniversary celebrations of the Council of Scientific and Industrial Research (CSIR), Prime Minister Narendra Modi said that the organisation had to gear themselves up to provide “time bound” delivery of solutions. Though the CSIR labs had immensely contributed to developing affordable technology — from tractors to diabetic drugs — for the country, it needed to ensure that there was no duplication of research efforts. “There should be a platform such that scientists learn what’s happening in one lab and then orient themselves to new challenges,” he told at the gathering of heads of CSIR labs and recepients of the Shanti Swarup Bhatnagar Awards, one of India’s most prestigious awards for scientists. He also exhorted scientists to be cognizant of technological solutions that needed to be immediately implemented, even as scientists worked on research that would yield fruit “50 or hundred years hence.”
The Prime Minister’s address was preceded by that of CSIR Director-General, Girish Sahni, who said that CSIR was launching a skill development programme that would see CSIR laboratories training the unskilled, in industrial applications. The CSIR, said Sahni, has identified 90 “fast track technologies,” developed by CSIR scientists that could be rapidly brought to market. Mr. Modi said concerns over water security were creating an atmosphere of “war brewing between countries over water” but said that it was scientists who had to come up with solutions. “Those who write about such things will write, but(CSIR) scientists have to do more over improving water security, ensuring that water can be used more efficiently and land used better to improve crop varieties.” Media reports said Mr. Modi is expected to be “briefed” on Monday by top government officials on the intricacies of India’s water treaty with Pakistan, The Indus Treaty. This discussion is in the context of the attack at Uri that saw 17 soldiers killed by Pakistan-sponsored terrorists.
LUCKNOW: A herbal cough syrup, with no alcohol and known to be effective in allergic coughs, was released by Central Institute of Medicinaland Aromatic Plants on Monday. After four years of research, the institute has come up with the syrup made up of three herbs; Tulsi, Kantakari (known for effective treatment of asthma, cough and chest pain) and Cinnamon, popularly know as Dal Chini.
“The syrup has been made with CIM-Angan, Shyama Tulsi variety of CIMAP that has medicinal properties. It is active against an allergic cough,” said senior scientist DN Mani who led the team. “The syrup has been officially released during the CSIR 74th foundation day and will reach the public once the institute offers the technology to a firm that shows interest in the formulation,” said scientist Sanjay Kumar.
The finding could give impetus to therapies of various age-related diseases. (Representative image) PUNE: Finding a rare, genetic mutation is a tough task, and expensive too. A pan-India doctors’ and researchers’ consortium came to the Kapse’s rescue when they wished to have another child. During the time when Sayli and Siddhant’s initial treatment at D Y Patil Medical College and Hospital in Pimpri, the treating dermatologist researched on genetic diseases along with scientists at the Institute of Genomics and Integrative Biology (IGIB) in New Delhi, a premier Institute of Council of Scientific and Industrial Research (CSIR),.
“We went in for something called whole Exome Sequencing that means sequencing the entire coding region of the person’s DNA. We did this for the entire all the four family members. The cost of this procedure, which runs into lakhs, was borne by IGIB,” said dermatologist Aayush Gupta, the siblings’ doctor. In a year, Gupta and other researchers at IGIB were able to find the exact cause of the disease. “We found a mutation in the tgm1 gene. With that exact mutation found we were then able to fulfil the family’s dream of the family to have a normal kid in the third pregnancy,” Gupta said. Thirty-two-year-old Sarika Kapse, mother of Sayli and Siddhant’s mother Sarika (32) conceived again. At twelve weeks, she got the foetus prenatally tested for the mutation the doctors had found earlier. “The foetus had only one such copy of mutation and thus would be born normal. Since this rare skin disorder is an autosomal recessive genetic condition, it needs two copies of the mutated gene for the skin disorder to occur. And the foetus had only one such mutation. The mother was counselled to continue the pregnancy and she gave birth to a normal child in December 2015. This is important because though genetic diseases per say are incurable, they can be prevented, saving someone a lifetime of misery,” Gupta said. The diagnosis was made through the Genomics for Understanding Rare Diseases, India Alliance Network (GUARDIAN) programme that researchers Sridhar Sivasubbu and Vinod Scaria have cofounded. It is funded by CSIR.
“We extensively utilize genomics approaches and computational methods to identify the causative mutation in families suffering from rare genetic diseases. As part of the programme, we work extensively and closely with clinicians, who regularly see families suffering from rare genetic diseases,” said Scaria in an e-mail reply. GUARDIAN is a collaborative research programme towards understanding the genetic basis and molecular mechanisms underlying rare genetic disorders. The consortium today encompass over 100 clinicians and researchers from over 25 medical and research centres across the country, making it one of the largest clinical genomics research networks in India for rare diseases. “In many cases of rare genetic diseases, arriving at a precise diagnosis would enable appropriate treatment and in many cases prevention. Given the large burden of genetic diseases in India (approx 70 million) GUARDIAN provides the much needed technological and intellectual network to tackle these problem in India”.
The findings were part of a study conducted by the National Environmental Engineering Research Institute. An analysis of Delhi’s air pollution and future trends says that 60% of Delhi’s particulate matter pollution comes from neighbouring Haryana and Uttar Pradesh. Moreover, even if Delhi were to adopt the cleanest-grade fuel available, ensure that power plants in the vicinity adopt stringent emissions and ensure tidy pavements, pollution would persist well above globally-recommended safe levels, unless neighbouring states too adopted similarly stringent policies. Even if Delhi’s neighbours were to cooperate, it would at best halve Delhi’s pollution and still be short of the government-ideal of 40 microgram/cubic metre. This is because Delhi’s geographical location and land-use patterns are such that a fixed mass of particulate matter will persist. Delhi’s particulate matter pollution hovers between 300 and 900 microgram/cubic metre, depending on the weather. The findings were part of a study conducted by the National Environmental Engineering Research Institute (NEERI), a CSIR body, along with researchers the Austria-based International Institute for Applied Systems Analysis (IIAS). Though these findings are yet to
be peer-reviewed or published in a journal, they were discussed with officials at the Central Pollution Control Board at meeting on Wednesday. The researchers based their analysis on measurements of a range of sources of pollution — from burning biomass, vehicles, road-dust, cook-stoves — in Delhi. In their assessment, transport sector contributed nearly a fifth of the PM 2.5 — the ubiquitous residual particulate matter resulting from incomplete burning of matter — in Delhi. PM 2.5 is linked to respiratory diseases and cancer. However, the scientists didn’t disaggregate the relative role of big diesel cars and transport vehicles in pollution cause by ‘transport.’ Other key sources, in Delhi include the burning of biomass in cooking stoves, secondary inorganic aerosols from power plants and ammonia from agriculture. Attributing the sources of pollution in Delhi has been a controversial exercise with different experts, over the years, disputing the relative role of agriculture waste, vehicles, industry and road dust in exacerbating air pollution. “The research identifies a range of measures…including road paving to reduce road dust emission, a rapid transition to clean cooking fuels in Delhi and neighbouring states and managing agriculture and municipal waste,” said Padma Rao, senior scientist at NEERI and a co-author of the report. “Majority of Delhi’s pollution comes from outside with half from the surrounding states of Haryana and Uttar Pradesh, a quarter from sources even further away and a quarter from natural sources,” the authors said a in a press statement. “Even Pakistan is a contributor though there’s also pollution going out from India. We haven’t specifically modelled that,” Markus Amann of the IIAS, who led the study, told The Hindu. The study finds that nearly a fourth of the 15,000 tonnes of PM2.5 emitted annually is due to road dust and about 40% due to power plants and residual and commercial combustion. Road transport, in this estimate, contributes about 16%. If Delhi were to continue on its growth trajectory, road dust and burning waste would together become the biggest sources of pollution—about half put- together– by 2030, the NEERI analysis adds. The team arrived at their results through a modelling study—funded by the Department of Science and Technology—that accounted for the local meteorological conditions around Delhi, projected weather patterns into 2030, recorded traffic movement, as well as gauged emission patterns from commercial and private establishments. “Tackling the multiple sources of air pollution in Delhi…will not only reduce the estimated 8,900 premature deaths a year from air pollution in Delhi, but also cut the city’s greenhouse gas emissions,” said Amann. Delhi is among the world’s most polluted cities. In 2014, it was ranked the most polluted globally in terms of PM 2.5, by the World Health Organisation (WHO). In a May-update by the WHO, Delhi was toppled by Zabol, in Iran. Gwalior and Allahabad, meanwhile, came a close second and third in terms of PM 2.5, while Patna and Raipur are ranked 6th and 7th.